REX PRE™

About

Diet & exercise are the two most important pillars of a healthy lifestyle, and the two are intimately related. Without good nutrition, exercising becomes that much more difficult, but with better dieting practices, exercise capacity and all of its benefits are enhanced; Better Performance; Enhanced Body Composition; and Improved Quality of Life!

No matter what foods compose the majority of one’s diet, there’s nothing quite like the potency of a good pre workout; food simply cannot deliver the scientifically-proven doses of the best pre workout ingredients.

Unfortunately, most pre workouts can’t either! Or at least they chose not to.

That’s why we created REX PRE™ – a full-strength, clinically-dosed pre workout with the highest quality ketones available. Each scoop provides:

• Improved Endurance
• Amplified Energy
• Intensified Fat-Burning
• Increased Pain Tolerance
• Maximum Exercise Capacity
• Enhanced Focus
• Greater Blood Flow
• Elevated Strength

REX PRE™ wasn’t just formulated to be a good pre workout – it was made to take care of the specific needs of ketogenic athletes and the recreationally active.

One of the biggest complaints from lifters after they begin their keto diet is their relative lack of muscle pumps. With less available glucose, muscles during keto need a little boost to burn carbs during exercise and do more reps.

With citrulline and beta-alanine to drastically increase work capacity, whether in the gym or on the track, and complementary AmentoPump™, Muscle Pumps are restored in full.

That’s just a quick glimpse into the full potential of REX PRE™! Try the world’s best ketogenic pre workout to see the difference for yourself!

Uses

REX PRE™ can be used for all types of exercise by those following any type of diet to experience amplified training energy, exercise performance, and better blood flow.

Those already keto-adapted will benefit from the extra ketones to power exercise, while other ingredients work to help muscles utilize more glucose and perform better.

Those habitually consuming a carbohydrate-based diet will be able to reap the rewards of “dual fueling” – having both ketones and carbs to fuel performance – while boosting fat-burning.

For endurance exercise, use REX PRE™ 30-60 minutes prior to training.

For anaerobic exercise (weight training, sprinting, etc.), use REX PRE™ 20-30 minutes prior to training.

Supplement Facts

Ingredients

7,000mg Citrulline Malate

Citrulline is a non-proteogenic amino acid known to influence nitric oxide generation. Malate is a metabolic intermediate in the Kreb’s cycle – the principal pathway by which nutrients, especially fat and ketones, are metabolized.

• Citrulline is the most reliable amino acid for augmenting vasodilation and blood flow.
• For supplementation, citrulline is more advantageous than arginine, as most arginine is broken down during digestion, and never increases nitric oxide (the compound that produces vasodilation.
• Citrulline, however, is absorbed efficiently and, after entering the body, is converted to arginine – making it a better source for nitric oxide generation. With more nitric oxide, citrulline helps deliver more nutrients to working muscles, clear waste products, and enhance cellular volumization.
• Citrulline has also been observed to enhance glycogenolytic (muscle glycogen utilizing) enzymes. This can be particularly helpful to those who have spent extended durations low-carb, as these enzymes will be reduced, limiting the amount of high-intensity exercise that can be performed.
• This may be a reason citrulline supplementation has increased force output by over 20%.
• Citrulline also helps reduce soreness.
• Malate, as Citrulline Malate, is a proven workload capacity booster. Those supplementing with citrulline malate have been able to perform more repetitions during training and sustain performance.

4,000mg goBHB® Beta-Hydroxybutyrate

Beta-Hydroxybutyrate, or BHB, is an “alternative” fuel source – a ketone – produced when rates of cellular respiration are exceeded by rates of beta-oxidation of lipids. In other words, during a high-fat diet.

• BHB can be thought of as a short-chain fat, similar to MCTs, but smaller in size and better utilized throughout the body.
• Ketones have known therapeutic effects, such as promoting insulin sensitivity, antioxidant status, and cellular energy status.
• As it pertains to performance and the pre-workout period, adding supplemental ketones has been noted to alter cellular fuel preferences and extend endurance.
• This means that our muscles are able to utilize more fat, spare energy stores, and blunt lactic acid formation while enhancing time to exhaustion.
• Addition of BHB near exercise may accelerate recovery by increasing mammalian target of rapamycin (mTOR) signaling.

3,200mg Beta-Alanine

Comparable to how citrulline supplementation is superior to arginine supplementation for increasing body arginine levels, beta-alanine supplementation is superior to carnosine supplementation for increasing body carnosine levels.

• Carnosine is a cellular buffer, helping reduce muscle acidity.
• Protection from abrupt changes in pH is beta-alanine’s underlying cause for its ability to increase high-intensity exercise capacity, reduce fatigue, and increase power output.
• Long-term supplementation with beta-alanine leads to decreased fat mass and increased muscle, likely due to enhancing maximal training loads.
• Well-known for the “tingles” – a harmless “side effect” of beta-alanine supplementation known as paresthesia. This sensation will subside with extended use, and some are more sensitive than others based on genetic variations.

1,000mg Choline Bitartrate

Choline is a vitamin-like compound with a greater daily intake recommendation than all other vitamins (550mg) due to its role as a methyl donor and in neurological health.

• Recent investigations have discovered that almost everyone who does not eat eggs has insufficient choline intake.
• Choline helps with myelin formation, enhancing neuron signaling efficiency.
• Supplementation with choline has been shown to increase acetylcholine levels.
• Acetylcholine is a neurotransmitter involved in cell signaling, particularly at the neuromuscular junction, where it assists in muscular contractions.
• This has led to improved neuromuscular control – enhanced mind-muscle connection – and better overall cognition.

325mg Caffeine Anhydrous

Caffeine has earned its title of “world’s most popular supplement.” It is, indeed, the most used supplement in the world. Nearly 90% of Americans use caffeine daily, and over 50% consume more than 300mg.

• Caffeine antagonizes adenosine receptors to produce its most famous effects – increased wakefulness, attention, and energy.
• In addition to caffeine’s cognitive-enhancing abilities, it also stimulates an adrenaline release, boosting alertness and focus, body fat lipolysis, and pain tolerance.
• Collectively, caffeine use prior to training is useful for many reasons – it improves both aerobic and anaerobic performance (e.g., jogging and sprinting/lifting, respectively), fat oxidation and metabolic rate, total exercise tolerance, focus, and oxygen consumption.

100mg AmentoPump™ Amentoflavone

Amentoflavone is a flavonoid commonly found in herbals such as Ginkgo biloba and St. John’s Wort.

• Amentoflavone augments several molecular targets, including GABA receptors, cytochrome P450 3A4 and 2C9, and PDE5.
• With AmentoPump™, we are principally interested in PDE5 augmentation. PDE5 is the mechanism through which the most effective vasodilators in the world operate.
• By augmenting PDE5, amentoflavone is capable of increasing vasodilation, blood flow, and with the correct form of exercise, pumps.
• AmentoPump™ is included to work synergistically with Citrulline, as PDE5 inhibition allows more nitric oxide to carry out its function of enhancing vasodilation.

50mg Infinergy™ Dicaffeine Malate

Perhaps one of the only downsides of caffeine is it stops working too fast! Infinergy™ is composed of two caffeine molecules attached to a malic acid (just like the one from citrulline malate).

• In this form, caffeine is released over a spread out period of time, instead of all at once, such as with caffeine anhydrous or other forms of caffeine like coffee or tea.
• While common forms of caffeine stop working after 6-8 hours, Infinergy™ helps stave off the abruptness of a crash, letting you “come down” more gradually.

5mg Huperzia Serrata Extract

Huperzia Serrata contains the acetylcholinesterase inhibitor, huperzine A.

• While REX™ uses choline bitartrate to help increase acetylcholine levels, huperzine helps reduce the breakdown of existing acetylcholine for a 2-pronged approach of neuromuscular enhancement.
• Huperzine can be used as a nootropic and performance enhancer. Its effects as a nootropic are particularly robust, as it has high affinity for acetylcholinesterase inhibition in the brain.
• More than just a brain booster, huperzine also helps protect neurons from glutamate and other neurotoxins.

FAQs

Q: How Should I Take REX™?

A: As a dietary supplement, mix 1 serving (1 scoop) in 12-16oz of cold water and drink 20-30 minutes prior to weight lifting or explosive exercise or 30-60 minutes prior to endurance exercise.

Q: Why Would I Use REX™?

A: REX™ Ketogenic Pre Workout is the first BHB-based pre workout supplement with efficacious dosing and a fully transparent label, so you know exactly what you’re getting.

The ingredients in REX™ are proven, performance-enhancing supplements, and REX™ was designed to improve all aspects of performance, including endurance, power output, strength, energy, and focus.

Q: Will REX™ Augment Muscle Pumps?

A: While certain athletes will find it beneficial to NOT have any muscle pumps during exercise, lifters often complain that a ketogenic diet “reduces” pumps during training, but there are many factors to pumps.

Everything regarding pumps stays the same except there’s a reduction in lactic acid accumulation because lactic acid is produced from carbohydrate metabolism.

Because pumps are dependent on the type of exercise performed, REX™ will NOT increase pumps during all types of exercise. Rather, REX™ increases blood flow and the potential for vasodilation.

Therefore, REX™ will help clear metabolic wastes during low to moderate intensity activity, as that type of exercise increases both directions of blood flow (to and away from the muscle). With resistance exercise, thought, the type of exercise preferentially drives blood towards muscle, and REX™ helps create an “overload” effect, strengthening pumps!

Q: Can I Stack REX™ with Any Other Archetype Products?

A: Yes! REX™ works extremely well with Keto SuperCarb™ consumed during exercise. REX™ provides the energy and Keto SuperCarb™ provides the fuel for the most effective training sessions.

Science

Citrulline Malate

1. Giannesini, B., Le Fur, Y., Cozzone, P. J., Verleye, M., Le Guern, M. E., & Bendahan, D. (2011). Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle. European journal of pharmacology, 667(1-3), 100-104.
2. Van Wijck, K., Wijnands, K. A., Meesters, D. M., Boonen, B., Van Loon, L. J., Buurman, W. A., ... & Poeze, M. (2014). L-citrulline improves splanchnic perfusion and reduces gut injury during exercise. Medicine & Science in Sports & Exercise, 46(11), 2039-2046.
3. Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. The Journal of Strength & Conditioning Research, 24(5), 1215-1222.
4. Moinard, C., Nicolis, I., Neveux, N., Darquy, S., Benazeth, S., & Cynober, L. (2008). Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study. British journal of nutrition, 99(4), 855-862.
5. Joy, J. M., Vogel, R. M., Falcone, P. H., Mosman, M. M., Tribby, A. C., Hughes, C. M., ... & Kim, M. P. (2015). A comparison of raw citrulline and citrulline peptide for increasing exercise-induced vasodilation and blood flow. Journal of the International Society of Sports Nutrition, 12(1), P18.
6. Moon, J. R., Vogel, R. M., Falcone, P. H., Mosman, M. M., Tribby, A. C., Hughes, C. M., ... & Joy, J., M. (2015). A comparison of citrulline and arginine for increasing exercise-induced vasodilation and blood flow. Journal of the International Society of Sports Nutrition, 12(1), P6.
7. Ochiai, M., Hayashi, T., Morita, M., Ina, K., Maeda, M., Watanabe, F., & Morishita, K. (2012). Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. International journal of cardiology, 155(2), 257-261.

BHB

1. Veech, R. L. (2004). The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins, leukotrienes and essential fatty acids, 70(3), 309-319.
2. Vandoorne, T., De Smet, S., Ramaekers, M., Van Thienen, R., De Bock, K., Clarke, K., & Hespel, P. (2017). Intake of a ketone ester drink during recovery from exercise promotes mTORC1 signaling but not glycogen resynthesis in human muscle. Frontiers in physiology, 8, 310.
3. Cox, P. J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., ... & King, M. T. (2016). Nutritional ketosis alters fuel preference and thereby endurance performance in athletes. Cell metabolism, 24(2), 256-268.
4. Holdsworth, D. A., Cox, P. J., Kirk, T., Stradling, H., Impey, S. G., & Clarke, K. (2017). A ketone ester drink increases postexercise muscle glycogen synthesis in humans. Medicine and science in sports and exercise, 49(9), 1789.

Beta-Alanine

1. Walter, A. A., Smith, A. E., Kendall, K. L., Stout, J. R., & Cramer, J. T. (2010). Six weeks of high-intensity interval training with and without β-alanine supplementation for improving cardiovascular fitness in women. The Journal of Strength & Conditioning Research, 24(5), 1199-1207.
2. Smith, A. E., Walter, A. A., Graef, J. L., Kendall, K. L., Moon, J. R., Lockwood, C. M., ... & Stout, J. R. (2009). Effects of β-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial. Journal of the International Society of Sports Nutrition, 6(1), 5.
3. Stout, J. R., Cramer, J. T., Zoeller, R. F., Torok, D., Costa, P., Hoffman, J. R., ... & O’kroy, J. (2007). Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino acids, 32(3), 381-386.
4. Hoffman, J. R., Ratamess, N. A., Faigenbaum, A. D., Ross, R., Kang, J., Stout, J. R., & Wise, J. A. (2008). Short-duration β-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players. Nutrition research, 28(1), 31-35.
5. Sale, C., Saunders, B., Hudson, S., Wise, J. A., Harris, R. C., & Sunderland, C. D. (2011). Effect of β-alanine plus sodium bicarbonate on high-intensity cycling capacity. Medicine and science in sports and exercise, 43(10), 1972-1978.
6. Baguet, A., Bourgois, J., Vanhee, L., Achten, E., & Derave, W. (2010). Important role of muscle carnosine in rowing performance. Journal of applied physiology, 109(4), 1096-1101.
7. Hoffman, J., Ratamess, N. A., Ross, R., Kang, J., Magrelli, J., Neese, K., ... & Wise, J. A. (2008). β-Alanine and the hormonal response to exercise. International journal of sports medicine, 29(12), 952-958.
8. Kern, B. D., & Robinson, T. L. (2011). Effects of β-alanine supplementation on performance and body composition in collegiate wrestlers and football players. The Journal of Strength & Conditioning Research, 25(7), 1804-1815.

Choline

1. Wallace, T., & Fulgoni, V. (2017). Usual choline intakes are associated with egg and protein food consumption in the United States. Nutrients, 9(8), 839.
2. Brody, T. (2016). Food and Dietary Supplement Package Labeling—Guidance from FDA's Warning Letters and Title 21 of the Code of Federal Regulations. Comprehensive Reviews in Food Science and Food Safety, 15(1), 92-129.
3. Skripuletz, T., Manzel, A., Gropengießer, K., Schäfer, N., Gudi, V., Singh, V., ... & Vulinovic, F. (2014). Pivotal role of choline metabolites in remyelination. Brain, 138(2), 398-413.
4. Naber, M., Hommel, B., & Colzato, L. S. (2015). Improved human visuomotor performance and pupil constriction after choline supplementation in a placebo-controlled double-blind study. Scientific reports, 5, 13188.
5. Köppen, A., Klein, J., Erb, C., & Löffelholz, K. (1997). Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide. Journal of Pharmacology and Experimental Therapeutics, 282(3), 1139-1145.

Caffeine

1. Paton, C. D., Lowe, T., & Irvine, A. (2010). Caffeinated chewing gum increases repeated sprint performance and augments increases in testosterone in competitive cyclists. European journal of applied physiology, 110(6), 1243-1250.
2. Carr, A. J., Gore, C. J., & Dawson, B. (2011). Induced alkalosis and caffeine supplementation: effects on 2,000-m rowing performance. International journal of sport nutrition and exercise metabolism, 21(5), 357-364.
3. Del Coso, J., Salinero, J. J., González-Millán, C., Abián-Vicén, J., & Pérez-González, B. (2012). Dose response effects of a caffeine-containing energy drink on muscle performance: a repeated measures design. Journal of the International Society of Sports Nutrition, 9(1), 21.
4. Mora-Rodríguez, R., Pallarés, J. G., López-Samanes, Á., Ortega, J. F., & Fernández-Elías, V. E. (2012). Caffeine ingestion reverses the circadian rhythm effects on neuromuscular performance in highly resistance-trained men. PLoS One, 7(4), e33807.
5. Anderson, D. E., & Hickey, M. S. (1994). Effects of caffeine on the metabolic and catecholamine responses to exercise in 5 and 28 degrees C. Medicine and science in sports and exercise, 26(4), 453-458.
6. Desbrow, B., Biddulph, C., Devlin, B., Grant, G. D., Anoopkumar-Dukie, S., & Leveritt, M. D. (2012). The effects of different doses of caffeine on endurance cycling time trial performance. Journal of sports sciences, 30(2), 115-120.
7. Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., & Madsen, J. (1990). Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American journal of clinical nutrition, 51(5), 759-767.
8. Bellar, D., Kamimori, G. H., & Glickman, E. L. (2011). The effects of low-dose caffeine on perceived pain during a grip to exhaustion task. The Journal of Strength & Conditioning Research, 25(5), 1225-1228.
9. Duncan, M. J., & Oxford, S. W. (2011). The effect of caffeine ingestion on mood state and bench press performance to failure. The Journal of Strength & Conditioning Research, 25(1), 178-185.
10. Schneiker, K. T., Bishop, D., Dawson, B., & Hackett, L. P. (2006). Effects of caffeine on prolonged intermittent-sprint ability in team-sport athletes. Medicine and science in sports and exercise, 38(3), 578-585.
11. Karapetian, G. K., Engels, H. J., Gretebeck, K. A., & Gretebeck, R. J. (2012). Effect of caffeine on LT, VT and HRVT. International journal of sports medicine, 33(07), 507-513.
12. Sommerfeld, A., & Witherly, S. (2014). S. Patent No. 8,642,095. Washington, DC: U.S. Patent and Trademark Office.

Amentoflavone

1. Dell’Agli, M., Galli, G. V., & Bosisio, E. (2006). Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba. Planta medica, 72(05), 468-470.
2. Chaabi, M., Antheaume, C., Weniger, B., Justiniano, H., Lugnier, C., & Lobstein, A. (2007). Biflavones of Decussocarpus rospigliosii as phosphodiesterases inhibitors. Planta medica, 73(12), 1284-1286.
3. Kimura, Y., Ito, H., Ohnishi, R., & Hatano, T. (2010). Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity. Food and Chemical Toxicology, 48(1), 429-435.
4. Kang, D. G., Yin, M. H., Oh, H., Lee, D. H., & Lee, H. S. (2004). Vasorelaxation by amentoflavone isolated from Selaginella tamariscina. Planta medica, 70(08), 718-722.
5. XU, L., & YIN, M. H. (2009). Experiment study on vasodilative effects of amentoflavone ethyl acetate extract of selaginella tamariscina [J]. Journal of Medical Science Yanbian University, 4.
6. Woo, E. R., Lee, J. Y., Cho, I. J., Kim, S. G., & Kang, K. W. (2005). Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-κB activation in macrophages. Pharmacological Research, 51(6), 539-546.

Huperzine

1. Ma, T., Gong, K., Yan, Y., Zhang, L., Tang, P., Zhang, X., & Gong, Y. (2013). Huperzine A promotes hippocampal neurogenesis in vitro and in vivo. Brain research, 1506, 35-43.
2. Zhao, Q., & Tang, X. C. (2002). Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. European journal of pharmacology, 455(2-3), 101-107.
3. Ved, H. S., Koenig, M. L., Dave, J. R., & Doctor, B. P. (1997). Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport, 8(4), 963-967.
4. Kozikowski, A. P., & Tueckmantel, W. (1999). Chemistry, pharmacology, and clinical efficacy of the Chinese nootropic agent huperzine A. Accounts of chemical research, 32(8), 641-650.
5. Bai, D. (2007). Development of huperzine A and B for treatment of Alzheimer's disease. Pure and Applied Chemistry, 79(4), 469-479.