KETO FREE™ GDA

About

Keto diets are well known for being very low in carbohydrates. Overall, this helps us to live longer, healthier lives, as our bodies are best suited to survive on fat- and protein-based foods.

Carbohydrates, on the other hand, are optional. Although, they’re an option that we will occasionally choose to use, and there’s nothing wrong with that! In fact, it may be advantageous!

Infrequent “pulses” of carbohydrate help stimulate leptin release, potentiate fat loss, add lean muscle, and provide a reward for all of our daily hard work dieting!

Using a Glucose Disposal Agent, or GDA, prior to high-carb meals enhances the body’s ability to manage glucose and reap the benefits of carbs while mitigating any potential damage.

KETO FREE™ was designed to work systematically at multiple levels.

• Green Coffee Bean Extract – Limits carbohydrate enzymatic activity to limit the amount of simple sugars available for absorption.
• Green Tea Extract – Reduces glucose absorption and activates glucose transporters on muscle cells, but not fat cells, driving any absorbed glucose into muscle cells instead of being stored as fat.
• Olive Leaf Extract – Contains oleuropein and oleanolic acid, which facilitate fat loss and support enhanced insulin sensitivity.
• Berberine – An extremely effective glucose-disposing ingredient, used by many to reduce blood glucose and insulin response to carbohydrate-rich foods.
• Beta-Hydroxybutyrate (BHB) – Exogenous ketones, as BHB, have been proven to enhance glucose clearance from the blood and will accelerate a return to nutritional ketosis.

First, KETO FREE™ reduces total carbohydrate absorption from the digestive system. Second, any glucose that is absorbed is directed to be stored in the muscle, as glycogen, rather than in adipose cells, as fat. Finally, KETO FREE™ works to maintain ketosis by supplying exogenous BHB.

Choose KETO FREE™ so you can CHEAT FREE!

Uses

KETO FREE™ can be used for a variety of reasons and by anyone looking to reduce the negative impacts of a physique-destroying meal!

For keto dieters, use KETO FREE™:

1. Up to 3 times daily for improved blood glucose and insulin control.
2. Prior to an unplanned cheat meal to reduce any negative effects of excess glucose. Keep KETO FREE™ on you any time away from home without meals – you never know what comes up!
3. As part of a planned weekly cheat meal, cheat day, or refeed to direct carbs towards muscle. This will help “fill out” muscles and boost leptin levels to help maintain rates of fat loss during dieting.

For non-keto dieters, use KETO FREE™:

1. Up to 3 times daily for improved blood glucose, insulin, and body fat control.
2. Daily to provide nutrient partitioning effects, enhancing lean mass gain and fat loss.
3. Before cheat meals and re-feeds to increase the proportion of carbs that become functional and contribute to muscle size and performance.

Supplement Facts

Ingredients

Green Coffee Bean Extract

Green Coffee Bean is a highly concentrated source of the polyphenol, chlorogenic acid. Chlorogenic acids have many anti-glycemic and health benefits.

• Doses of at least 400mg chlorogenic acid reduce post-prandial (after eating) glucose and insulin levels
• This indicates that chlorogenic acid improves not just glucose and insulin concentrations, but that total insulin sensitivity is enhanced.
• Daily supplementation with chlorogenic acid from green coffee has been shown to improve weight loss efforts. Those using chlorogenic acid enriched coffee lost 3.7 more kilograms over 12 weeks than those in the normal coffee group.

Beta-hydroxybutyrate (BHB), as sodium, potassium, calcium, and magnesium BHB

BHB is an organic regulator of glucose levels. Increased blood BHB concentrations naturally reduce blood glucose levels.

• Administration of exogenous ketones may reduce circulating glucose levels by as much as 40%
• Quickly increases blood BHB, returning users to a state of ketosis following a high-carbohydrate meal.
• Supplementing with exogenous ketones limits excess body weight gain.
• BHB also improves mitochondrial health. As the mitochondria are the sites within cells that process macronutrients, our bodies are more adept at handling various types – and quantities – of carbs as well as fats and proteins.

Green Tea Leaf Extract

Green Tea is one of the richest sources of antioxidants and polyphenols around. It’s also a potent carbohydrate absorption inhibitor.

• Supplementing with EGCG-containing green tea has been noted to reduce carbohydrate absorption by 30% vs. placebo.
• EGCG and other components of green tea are believed to inhibit certain carb-specific enzymes along the digestive system.
• Catechins from green tea are also reported to suppress adipocyte differentiation and proliferation.
• When used alongside a cheat meal, this helps prevent accumulation of new or expanding fat cells, decreasing chances of unwanted body fat gain.

Berberine

Berberine is an alkaloid extracted from plants, primarily those in the berberis family. Its primary use is to augment glucose management and glucose response.

• Berberine supplementation decreases blood glucose, insulin, cholesterol, and glycation (HbA1C) while improving insulin sensitivity and nutrient partitioning.
• Berberine activates AMPK, causing a translocation of GLUT-4 (glucose transporters) to the cell surface, where they are then able to take glucose from the blood and bring it inside the cell to be metabolized.
• Berberine also confers protection to liver and pancreas cells, preserving optimal nutrient metabolism.

Olive Leaf Extract

Olive, including olive oil, is renowned for its beneficial health effects. Some of which come from olive leaf.

• Olive contains active constituents, such as oleuropein and oleanolic acid, which act as antioxidants, providing a host of benefits.
• Supplementing with olive leaf alongside 300g of rice reported an attenuation of the rise in blood glucose in excess of 50% vs. placebo.
• Olive leaf containing oleuropein improves pancreatic beta-cell responsiveness, supporting insulin regulation and sensitivity.
• In addition to glucose-regulating effects, olive leaf reduces general oxidation and DNA damage.

Vanadyl Sulfate

Vanadium is a nonessential mineral with insulin-sensitizing action favoring muscular uptake.

• Vanadium acts as a protein tyrosine phosphatase inhibitor.
• These compounds influence glucose uptake by increasing PI3K and GLUT4 mobilization.
• Vanadium’s effects on the aforementioned targets increases insulin sensitivity within muscle cells by 25%.
• By increasing muscular glucose uptake, muscle glycogen stores are more easily and rapidly replenished, improving workout performance.

FAQs

Q: Why Would I Use KETO FREE™?

A: Using a GDA, like KETO FREE™, prior to a high-carbohydrate meal is a good idea for every goal. For performance, a good GDA enhances rates of glycogen resynthesis – optimizing cellular energy for exercise. For body composition, KETO FREE™ redirects glucose (and fats) to muscle cells, preventing them from being stored inside fat cells. Ultimately, this helps the muscle cell understand it’s in an energy-rich environment and can proceed with recovery or muscle building, while the fat cell must begin to break down and decrease in size.

Q: How Do I Take KETO FREE™?

A: As a dietary supplement, take 1 serving (4 Capsules) of KETO FREE™ 20-30 minutes prior to a high-carb, nutrient-dense meal to optimize macronutrient utilization. Use up to 3 times daily for improved blood glucose control.

Q: I’m Keto; Why Would I Eat Carbs?

A: Carbohydrates are not an essential nutrient. In some forms, however, they are rather tasty, but that’s not the only reason. After ketosis is established (2-8 weeks of strict dieting), occasional carbohydrate consumption isn’t just acceptable, it is necessary to potentiate fat loss while improving physical performance and lean muscle. Occasional – once or twice per week – high-carb meals stimulate leptin release and other regulating agents that signal to the body it is okay to let go of some energy storages (body fat). For athletes, high intensity exercise can ONLY occur via anaerobic metabolism, and anaerobic metabolism can ONLY utilize carbohydrate. The good news is, athletes burn up WAY more carbs, so they can eat more! You can read all about it in our e-book, The New Rules of Keto!

Science

Green Coffee Bean / Chlorogenic Acid

1. Thom, E. (2007). The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. Journal of International Medical Research, 35(6), 900-908.
2. Van Dijk, A. E., Olthof, M. R., Meeuse, J. C., Seebus, E., Heine, R. J., & Van Dam, R. M. (2009). Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes care, 32(6), 1023-1025.
3. Karthikesan, K., Pari, L., & Menon, V. P. (2010). Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on streptozotocin-nicotinamide-induced diabetic rats. Gen Physiol Biophys, 29(1), 23-30.
4. Jin, S., Chang, C., Zhang, L., Liu, Y., Huang, X., & Chen, Z. (2015). Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice. PLoS One, 10(4), e0120842.
5. Cho, A. S., Jeon, S. M., Kim, M. J., Yeo, J., Seo, K. I., Choi, M. S., & Lee, M. K. (2010). Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food and Chemical Toxicology, 48(3), 937-943.
6. Vinson, J. A., Burnham, B. R., & Nagendran, M. V. (2012). Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes, metabolic syndrome and obesity: targets and therapy, 5, 21.
7. Lee, A. H., L'B, T., Hiramatsu, N., Ishisaka, A., Alfonso, H., Tanaka, A., ... & Takechi, R. (2016). Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women. Nutrition & diabetes, 6(6), e212.

Beta-Hydroxybutyrate (BHB)

1. Kesl, S. L., Poff, A. M., Ward, N. P., Fiorelli, T. N., Ari, C., Van Putten, A. J., ... & D’Agostino, D. P. (2016). Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats. Nutrition & metabolism, 13(1), 9.
2. Tieu, K., Perier, C., Caspersen, C., Teismann, P., Wu, D. C., Yan, S. D., ... & Przedborski, S. (2003). D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. The Journal of clinical investigation, 112(6), 892-901.
3. Veech, R. L. (2004). The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins, leukotrienes and essential fatty acids, 70(3), 309-319.
4. Veech, R. L., Chance, B., Kashiwaya, Y., Lardy, H. A., & Cahill Jr, G. F. (2001). Ketone bodies, potential therapeutic uses. IUBMB life, 51(4), 241-247.
5. Srivastava, S., Kashiwaya, Y., King, M. T., Baxa, U., Tam, J., Niu, G., ... & Veech, R. L. (2012). Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet. The FASEB Journal, 26(6), 2351-2362.

Green Tea

1. Lochocka, K., Bajerska, J., Glapa, A., Fidler-Witon, E., Nowak, J. K., Szczapa, T., ... & Walkowiak, J. (2015). Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study. Scientific reports, 5, 12015.
2. Miao, M., Jiang, B., Jiang, H., Zhang, T., & Li, X. (2015). Interaction mechanism between green tea extract and human α-amylase for reducing starch digestion. Food chemistry, 186, 20-25.
3. Yilmazer-Musa, M., Griffith, A. M., Michels, A. J., Schneider, E., & Frei, B. (2012). Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. Journal of agricultural and food chemistry, 60(36), 8924-8929.
4. Venables, M. C., Hulston, C. J., Cox, H. R., & Jeukendrup, A. E. (2008). Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. The American journal of clinical nutrition, 87(3), 778-784.
5. Wu, A. H., Spicer, D., Stanczyk, F. Z., Tseng, C. C., Yang, C. S., & Pike, M. C. (2012). Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women. Cancer Prevention Research, 5(3), 393-402.
6. Hua, C. H., Liao, Y. L., Lin, S. C., Tsai, T. H., Huang, C. J., & Chou, P. (2011). Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebocontrolled clinical trial. Alternative Medicine Review, 16(2), 157-163.
7. Hursel, R., Viechtbauer, W., Dulloo, A. G., Tremblay, A., Tappy, L., Rumpler, W., & Westerterp‐Plantenga, M. S. (2011). The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta‐Obesity reviews, 12(7), e573-e581.

Berberine

1. Dong, H., Wang, N., Zhao, L., & Lu, F. (2012). Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine, 2012.
2. Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., ... & Ren, G. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. The Journal of Clinical Endocrinology & Metabolism, 93(7), 2559-2565.
3. Zhou, J., Zhou, S., Tang, J., Zhang, K., Guang, L., Huang, Y., ... & Li, D. (2009). Protective effect of berberine on beta cells in streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats. European Journal of Pharmacology, 606(1-3), 262-268.
4. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., ... & Pan, H. N. (2010). Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism, 59(2), 285-292.
5. Gu, J. J., Gao, F. Y., & Zhao, T. Y. (2012). A preliminary investigation of the mechanisms underlying the effect of berberine in preventing high-fat diet-induced insulin resistance in rats. J Physiol Pharmacol, 63(5), 505-513.

Olive Leaf Extract

1. KOMAKI, E., YAMAGUCHI, S., MARU, I., KINOSHITA, M., KAKEHI, K., OHTA, Y., & TSUKADA, Y. (2003). Identification of anti-α-amylase components from olive leaf extracts. Food Science and Technology Research, 9(1), 35-39.
2. Covas, M. I., de la Torre, K., Farré-Albaladejo, M., Kaikkonen, J., Fitó, M., López-Sabater, C., ... & de la Torre, R. (2006). Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans. Free Radical Biology and Medicine, 40(4), 608-616.
3. Castaner, O., Covas, M. I., Khymenets, O., Nyyssonen, K., Konstantinidou, V., Zunft, H. F., ... & Fito, M. (2012). Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans. The American journal of clinical nutrition, 95(5), 1238-1244.
4. Susalit, E., Agus, N., Effendi, I., Tjandrawinata, R. R., Nofiarny, D., Perrinjaquet-Moccetti, T., & Verbruggen, M. (2011). Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine, 18(4), 251-258.
5. Weinbrenner, T., Fito, M., Torre, R. D. L., Saez, G. T., Rijken, P., Tormos, C., ... & Marrugat, J. (2004). Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men. The Journal of nutrition, 134(9), 2314-2321.
6. de Bock, M., Derraik, J. G., Brennan, C. M., Biggs, J. B., Morgan, P. E., Hodgkinson, S. C., ... & Cutfield, W. S. (2013). Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PloS one, 8(3), e57622.

Vanadyl Sulfate

1. O’Connor, J. C., & Freund, G. G. (2003). Vanadate and rapamycin synergistically enhance insulin-stimulated glucose uptake. Metabolism, 52(6), 666-674.
2. Cusi, K., Cukier, S., DeFronzo, R. A., Torres, M., Puchulu, F. M., & Redondo, J. P. (2001). Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. The Journal of Clinical Endocrinology & Metabolism, 86(3), 1410-1417.
3. Cohen, N., Halberstam, M., Shlimovich, P., Chang, C. J., Shamoon, H., & Rossetti, L. (1995). Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. The Journal of clinical investigation, 95(6), 2501-2509.
4. Sakurai, H. (2002). A new concept: the use of vanadium complexes in the treatment of diabetes mellitus. The Chemical Record, 2(4), 237-248.
5. Tsiani, E., Bogdanovic, E., Sorisky, A., Nagy, L., & Fantus, I. G. (1998). Tyrosine phosphatase inhibitors, vanadate and pervanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of phosphatidylinositol 3-kinase and protein kinase C. Diabetes, 47(11), 1676-1686.